Is chromogranin a prohormone?
نویسندگان
چکیده
منابع مشابه
Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway.
Chromogranins A and B and secretogranin II are a family of acidic proteins found in neuroendocrine secretory vesicles; these proteins contain multiple potential cleavage sites for proteolytic processing by the mammalian subtilisin-like serine endoproteases PC1 and PC2 (prohormone convertases 1 and 2), and furin. We explored the role of these endoproteases in chromogranin processing in AtT-20 mo...
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Human chromogranin A (CgA) is a secretory protein that is used as a tissue marker for neuroendocrine tumors (NETs) (1,2). In patients with carcinoids and pheochromocytomas, CgA is a more stable marker than plasma levels of serotonin, catecholamines and their urinary metabolites (3). It may also be elevated due to several other causes; however, the use of proton pump inhibitors (PPIs) is the mos...
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"There appears to be a direct correlation between tumor burden and serum CgA levels. Rising serum levels of CgA can predeed radiographic evidence of recurrence. . . . .Using serum CgA level above 30 U/ml, one is able to discriminate between disease free patients and those with recurrent metastatic disease with a sensitivity of 92% and specificity of 96%. This is superior to measuring urinary 5-...
متن کامل[Chromogranin A and neuroendocrine tumors].
Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Despite the limitations of testing methods, which require careful interpretation, especially in the case of gastrinomas, patients treated with somatostatin analogues, and poorly differentiated tumors, it is the best tumor marker ...
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Since the initial demonstration of increased circulating norepinephrine in patients with chronic heart failure, a large number of investigations on neuroendocrine activation in heart failure have followed. It is now clear that persistent activation of neuroendocrine systems, notably the adrenergic system and the renin–angiotensin system is maladaptive in heart failure (reviewed in). In this iss...
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ژورنال
عنوان ژورنال: Nature
سال: 1987
ISSN: 0028-0836,1476-4687
DOI: 10.1038/325301a0